SGS1/BLM suppresses R-loop formation 1 Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instability
نویسندگان
چکیده
1 Terry Fox Laboratory, BC Cancer Agency, Vancouver BC, Canada V5Z 1L3 2 Centre for Molecular Medicine and Therapeutics, Vancouver BC, Canada V5Z 4H4 3 Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R 2J6, Canada 4 Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Québec City, QC G1V 0A6, Canada 5 Michael Smith Genome Sciences Centre, Vancouver BC, Canada V5Z 4S6 6 Department of Medical Genetics, University of British Columbia, Vancouver BC, Canada V6T 1Z4 C.A.N. and E.Y.C contributed equally to this work
منابع مشابه
Sumoylation of the BLM ortholog, Sgs1, promotes telomere–telomere recombination in budding yeast
BLM and WRN are members of the RecQ family of DNA helicases, and in humans their loss is associated with syndromes characterized by genome instability and cancer predisposition. As the only RecQ DNA helicase in the yeast Saccharomyces cerevisiae, Sgs1 is known to safeguard genome integrity through its role in DNA recombination. Interestingly, WRN, BLM and Sgs1 are all known to be modified by th...
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Bloom's helicase (BLM) is thought to prevent crossing-over during DNA double-strand-break repair (DSBR) by disassembling double-Holliday junctions (dHJs) or by preventing their formation. We show that the Saccharomyces cerevisiae BLM ortholog, Sgs1, prevents aberrant crossing-over during meiosis by suppressing formation of joint molecules (JMs) comprising three and four interconnected duplexes....
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تاریخ انتشار 2017